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Disulfite-induced acute intermittent urticaria with vasculitis

B Wüthrich1, M K Kägi, J Hafner

  • 1Department of Dermatology University Hospital, Zurich, Switzerland.

Dermatology (Basel, Switzerland)
|January 1, 1993
PubMed
Summary

Sulfite sensitivity can cause severe allergic reactions like urticaria and leukocytoclastic vasculitis. Patients require emergency kits due to the widespread use of sulfites in foods and medications.

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Area of Science:

  • Dermatology
  • Allergology
  • Immunology

Background:

  • Sulfite additives are common in foods and medications, potentially triggering adverse reactions.
  • Dermatologists must recognize sulfite sensitivity due to its increasing clinical importance.

Observation:

  • A 47-year-old man presented with severe acute intermittent urticaria.
  • A controlled oral challenge with sodium disulfite precipitated an urticaria episode.

Findings:

  • Biopsy revealed leukocytoclastic vasculitis with eosinophilia 5 hours post-urticaria.
  • This case highlights a severe cutaneous reaction to sulfite ingestion.

Implications:

  • Avoiding sulfites is challenging due to their prevalence.
  • Patients with sulfite sensitivity should carry a medical emergency kit.

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