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SOS mutagenesis
1Department of Biology, Massachusetts Institute of Technology, Cambridge 02139.
Current Opinion in Genetics & Development
|October 1, 1993
Abstract:
In Escherichia coli, UV and many chemicals appear to cause mutagenesis by a process of translesion synthesis that requires some form of DNA polymerase III and the SOS-regulated proteins UmuD, UmuC and RecA. An analysis of SOS mutagenesis offers insights into the molecular basis of induced mutagenesis and into mechanisms of DNA damage tolerance.