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Cancer-associated fasciitis panniculitis
J E Naschitz1, D Yeshurun, E Zuckerman
1Department of Internal Medicine A, Bnai-Zion Medical Center, Haifa, Israel.
Cancer
|January 1, 1994
Summary
Fasciitis panniculitis syndrome (FPS) associated with cancer often presents before malignancy diagnosis and typically affects women. This cancer-associated FPS is distinct from idiopathic FPS, showing resistance to prednisone therapy.
Area of Science:
- Dermatology
- Oncology
- Pathology
Background:
- Eosinophilic fasciitis and fasciitis panniculitis syndrome (FPS) involve chronic inflammation and fibrous thickening of subcutaneous tissues.
- FPS associated with cancer is a rare but recognized paraneoplastic phenomenon.
Observation:
- This study analyzed 12 cases of cancer-associated FPS, including 3 new cases and 9 from literature.
- The analysis focused on identifying distinguishing features compared to FPS without malignancy.
Findings:
- Cancer-associated FPS demonstrated a female predominance (8/12 patients) and a strong link to hematolymphatic malignancies (9/12 patients).
- In most cases (10/12), FPS preceded the cancer diagnosis by a median of 1 year.
- The majority of patients (7/8) with cancer-associated FPS were unresponsive to prednisone therapy.
Implications:
- Cancer-associated FPS exhibits characteristics of a paraneoplastic syndrome, occurring distantly from the tumor and sometimes resolving post-surgery.
- Unlike idiopathic FPS, cancer-associated FPS shows a female predilection and poor response to corticosteroids, suggesting distinct underlying mechanisms.