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Related Experiment Videos

Dextromethorphan O-demethylation polymorphism in Jordanians

Y M Irshaid1, H F al-Hadidi, N M Rawashdeh

  • 1Department of Pharmacology, Faculty of Medicine, University of Science and Technology, Irbid, Jordan.

European Journal of Clinical Pharmacology
|January 1, 1993
PubMed
Summary

This study investigated dextromethorphan (DMT) metabolism in Jordanian volunteers. Poor metaboliser phenotype frequency was 2.9%, indicating genetic variations in drug processing.

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Area of Science:

  • Pharmacogenetics
  • Drug Metabolism
  • Clinical Pharmacology

Background:

  • Dextromethorphan (DMT) is a widely used antitussive agent.
  • Its metabolism primarily involves O-demethylation to dextrorphan (DRP) via cytochrome P450 enzymes.
  • Genetic variations in these enzymes can lead to significant inter-individual differences in drug response.

Purpose of the Study:

  • To determine the frequency of the poor metaboliser phenotype for dextromethorphan (DMT) in a healthy Jordanian population.
  • To estimate the allele frequency of the gene responsible for poor metabolism using the Hardy-Weinberg Law.

Main Methods:

  • A cohort of 241 unrelated, healthy Jordanian volunteers (171 males, 70 females) participated.
  • Urine samples were collected for 8 hours after a single oral dose of 30 mg DMT bromhydrate.

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  • Metaboliser phenotype was identified using a thin-layer chromatographic (TLC) technique.

    • Main Results:

    • The frequency of the poor metaboliser phenotype was determined to be 2.9% (95% CI: 0.8-5.0%).
    • The estimated frequency of the recessive autosomal gene controlling poor metabolism was 0.17 (95% CI: 0.108-0.232) based on Hardy-Weinberg equilibrium.

    Conclusions:

    • The prevalence of poor dextromethorphan (DMT) metabolism in Jordanians is relatively low compared to some other populations.
    • These findings contribute to understanding population-specific pharmacogenetic variations in drug metabolism.
    • The data provides a basis for further research into the clinical implications of DMT metabolism in this demographic.