Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acetylator polymorphism in rheumatoid arthritis

J M Ladero1, M P Andres, A Bañares

  • 1Department of Medicine, Hospital Universitario San Carlos, Universidad Complutense, Madrid, Spain.

European Journal of Clinical Pharmacology
|January 1, 1993
PubMed
Summary

Rapid acetylator phenotype may increase the risk of severe rheumatoid arthritis in women. This study analyzed acetylator status using sulphamethazine in Spanish rheumatoid arthritis patients and controls.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single-use, low-profile flexible ureterorenoscopy in paediatric lithiasis: Preliminary experience expanding the boundaries of ESPU recommendations.

Journal of pediatric surgery·2026
Same author

Extra-hepatic cholangiocarcinoma diagnosis: from classical pathological analysis to the emerging omics tests.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026
Same author

Single-event fast neutron time-of-flight spectrometry with a petawatt-laser-driven neutron source.

Nature communications·2026
Same author

COSMONAUT: A COmpact spectrometer for measurements of neutrons at the ASDEX upgrade tokamak.

The Review of scientific instruments·2024
Same author

Fungal Planet description sheets: 1436-1477.

Persoonia·2024
Same author

Fungal Planet description sheets: 1284-1382.

Persoonia·2023

Area of Science:

  • Pharmacogenetics
  • Rheumatology
  • Clinical Pharmacology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease affecting joints.
  • Acetylator phenotype, influenced by drug metabolism, may play a role in RA pathogenesis.
  • Understanding genetic factors in RA can improve treatment strategies.

Purpose of the Study:

  • To investigate the association between acetylator phenotype and rheumatoid arthritis in a Spanish population.
  • To determine if specific acetylator phenotypes are more prevalent in RA patients compared to healthy controls.
  • To explore potential sex-based differences in this association.

Main Methods:

  • Acetylator phenotype was determined using sulphamethazine (sulphadimidine).
  • The study included 69 Spanish patients with rheumatoid arthritis and 96 age-matched healthy controls.

Related Experiment Videos

  • Data were analyzed for the overall group and separately for males and females.

    • Main Results:

    • Overall, 46.4% of RA patients and 58.3% of controls were slow acetylators.
    • In females, 37.5% of RA patients and 63% of controls were slow acetylators.
    • No significant difference in slow acetylator prevalence was observed between male patients and controls.

    Conclusions:

    • A rapid acetylator phenotype may be a risk factor for developing severe rheumatoid arthritis in women.
    • The findings suggest a potential sex-specific genetic influence on RA development.
    • Further research is warranted to confirm these pharmacogenetic associations in rheumatoid arthritis.