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Cocaine and several sigma receptor ligands inhibit dopamine uptake in rat caudate-putamen
S Izenwasser1, A H Newman, J L Katz
1Psychobiology Section, NIDA Addiction Research Center, Baltimore, MD 21224.
European Journal of Pharmacology
|October 19, 1993
Abstract:
Cocaine and several sigma receptor ligands inhibit dopamine uptake via a common site. This is evidenced by a concentration-dependent inhibition of dopamine uptake and displacement of the binding of [3H]WIN 35,428 (also called CFT), a cocaine analog with high affinity for the dopamine transporter. Since several sigma receptor ligands have been shown to block the stimulant effects of cocaine, this site may serve as a target for future drug development to treat cocaine abuse.