Related Experiment Videos
Modulation of feeding and drinking by dopamine in caudate and accumbens nuclei in rats
1Department of Physiology, Jawaharlal Institute of Postgraduate Medical Education and Research Pondicherry, India.
Indian Journal of Experimental Biology
|September 1, 1993
Abstract:
Injection of dopamine (DA) into accumbens and caudate nuclei facilitates a dose-dependent increase in food and water intake, whereas administration of spiperone (SP), a central D2-receptor antagonist suppresses DA-facilitated food and water intake. Bilateral lesions of nucleus accumbens and caudatus result in a sustained and significant decrease in food and water intake. The results suggest that DA is a neurotransmitter involved in feeding and drinking behavior in accumbens and caudate nuclei and this effect is mediated by central D2 receptors.