Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Study on the reference dose level in radiotherapy treatment planning

L Begnozzi1, F P Gentile, L Chiatti

  • 1Laboratorio Fisica Medica e Sistemi Esperti, C.R.S. Istituto Regina Elena per lo Studio e la Cura dei Tumori, Roma, Italy.

International Journal of Radiation Oncology, Biology, Physics
|January 15, 1994
PubMed
Summary

This study investigates the reference dose level in tumor radiotherapy, finding it

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Concussed patients with visually induced dizziness exhibit increased ocular torsion and vertical vergence during optokinetic gaze-stabilization.

Scientific reports·2023
Same author

The lost ability to distinguish between self and other voice following a brain lesion.

NeuroImage. Clinical·2018
Same author

Visual perception skills: a comparison between patients with Noonan syndrome and 22q11.2 deletion syndrome.

Genes, brain, and behavior·2017
Same author

Monte Carlo based calibration of an air monitoring system for gamma and beta+ radiation.

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine·2015
Same author

Step-and-Shoot IMRT by Siemens Beams: An EPID Dosimetry Verification During Treatment.

Technology in cancer research & treatment·2015
Same author

Historia magistra vitae (Cic. De or. 2.36). The Prime Objective of Radiosurgery in Acoustic Neurinomas.

The neuroradiology journal·2013

Area of Science:

  • Radiation Oncology
  • Medical Physics

Background:

  • Accurate dose prescription is crucial for effective tumor control and minimizing side effects.
  • The reference dose level guides radiotherapy prescription, but its determination can be complex with non-uniform dose distributions.

Purpose of the Study:

  • To investigate the reference dose level within the tumor volume based on dose distribution.
  • To evaluate how dose-volume histogram (DVH) shape, total dose, fraction size, and Linear-Quadratic (LQ) model parameters influence the reference dose level.

Main Methods:

  • Utilized a formula derived from the Linear-Quadratic (LQ) model.
  • Simulated various dose distributions and DVH shapes, varying parameters like total dose, fraction size, and LQ model parameters (alpha and beta).
  • Compared calculated reference dose levels with the ICRU 29 reference point dose for clinical treatment techniques.

Related Experiment Videos

Main Results:

  • The calculated reference dose level is consistently lower than the mean dose level, with the difference dependent on dose variation and tumor sensitivity.
  • High dose inhomogeneity results in a reference dose level significantly lower than the mean, but not necessarily the minimum dose.
  • For clinical techniques, reference levels sometimes fell below the ICRU 29 reference point dose, with equality observed in one four-beam technique case.

Conclusions:

  • Theoretical results suggest the potential to administer a higher prescribed dose to the tumor while maintaining the same Tumor Control Probability (TCP) as with uniform irradiation.
  • This study provides a framework for selecting an appropriate reference dose level based on actual dose distributions in the tumor volume.