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Novel oligosaccharides with the sialyl-Le(a) structure in human milk
H Kitagawa1, H Nakada, S Fukui
1Department of Biological Chemistry, Faculty of Pharmaceutical Sciences, Kyoto University.
Journal of Biochemistry
|October 1, 1993
Abstract:
Two novel oligosaccharides with the sialyl-Le(a) structure were isolated from human milk using a monoclonal antibody, MSW 113. These oligosaccharides were purified by affinity chromatography on a column of the immobilized monoclonal antibody and by high-performance liquid chromatography, and structurally characterized by a combination of 600-MHz 1H NMR spectroscopy and fast atom bombardment mass spectrometry. The structural studies indicated the structures of these oligosaccharides to be: [formula: see text]