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Keratoacanthoma

R A Schwartz1

  • 1New Jersey Medical School, Newark 07103-2714.

Journal of the American Academy of Dermatology
|January 1, 1994
PubMed
Summary

Keratoacanthoma, a common skin tumor, mimics cancer but rarely becomes invasive. This review details its clinical, histologic, and behavioral aspects for effective management.

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Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Keratoacanthoma is a frequent skin neoplasm, primarily affecting sun-exposed areas in fair-skinned individuals.
  • It is recognized as a pseudo-malignancy due to its rapid growth and histological similarity to squamous cell carcinoma.
  • Keratoacanthomas are believed to originate from hair follicle cells and are often considered an 'aborted malignancy'.

Purpose of the Study:

  • To provide a comprehensive overview of keratoacanthoma.
  • To discuss the clinical and histological characteristics of common keratoacanthoma and its variants.
  • To elucidate the biologic behavior and therapeutic responses associated with keratoacanthoma.

Main Methods:

  • Review of clinical and histological features of keratoacanthoma.
  • Analysis of biologic behavior and treatment outcomes.
  • Discussion of common type and variants.

Main Results:

  • Keratoacanthoma exhibits rapid growth and resembles squamous cell carcinoma histologically.
  • It rarely progresses to invasive squamous cell carcinoma.
  • Understanding its features aids in diagnosis and management.

Conclusions:

  • Keratoacanthoma is a distinct entity, often self-limiting, with a low potential for malignancy.
  • Accurate identification of its clinical and histological features is crucial.
  • Therapeutic strategies should be tailored to the specific presentation and behavior of the lesion.

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