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Genetic susceptibility to fixed drug eruption: evidence for a link with HLA-B22
R Pellicano1, G Ciavarella, M Lomuto
1Department of Dermatology, IRCCS, Casa Sollievo della Sofferenza Hospital, San Giovanni Rotondo, Italy.
Journal of the American Academy of Dermatology
|January 1, 1994
Abstract
Background:
Our observation of familial cases of fixed drug eruption (FDE) prompted us to consider a genetic predisposition to this disease.
Objective:
Our purpose was to determine whether there is any association between FDE and any of the major histocompatibility complex class I or II alleles.
Methods:
HLA class I and II typing was performed by lymphocytotoxicity assay in 36 unrelated patients with FDE.
Results:
Significantly higher (p < 0.0001) frequencies of the B22 and Cw1 antigens were found in the 36 patients with FDE.
Conclusion:
Our data are the first to suggest a genetic predisposition to FDE.