Related Experiment Videos
[Pharmacological studies on human urinary kallidinogenase (SK-827): effects on cerebral metabolism]
H Nagano1, T Suzuki, T Tomoguri
1Mie Research Laboratory, Sanwa Kagaku Kenkyusho Co., Ltd., Japan.
Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan
|November 1, 1993
Abstract:
We investigated the effects of human urinary kallidinogenase (SK-827) on cerebral metabolism in normal and infarcted rabbits. SK-827 did not influence cerebral glucose and oxygen uptake in normal rabbits. In infarcted rabbits, cerebral glucose and oxygen uptake significantly decreased. SK-827 tended to inhibit the decrease of cerebral blood flow, and significantly inhibited the decrease of cerebral glucose and oxygen uptake in infarcted rabbits. Thus, SK-827 improved cerebral glucose metabolism in infarcted rabbits.