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Sclerodermalike esophageal disease in children breast-fed by mothers with silicone breast implants
1Division of Pediatric Gastroenterology, Schneider Children's Hospital, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, NY 11042.
Insights
Breast-fed infants born to mothers with silicone implants showed abnormal esophageal motility. Further research is needed to confirm the link between silicone exposure and esophageal dysfunction in children.
Area of Science:
- Pediatric Gastroenterology
- Toxicology
- Immunology
Background:
- Silicone breast implants are widely used.
- Concerns exist regarding potential health effects of silicone exposure.
- Esophageal involvement in children exposed to silicone is not well-understood.
Purpose of the Study:
- To investigate the association between maternal silicone implants and esophageal motility in breast-fed children.
- To compare esophageal function in breast-fed infants exposed to silicone with unexposed controls.
Main Methods:
- A case-series study comparing 8 breast-fed children of mothers with silicone implants to 17 controls.
- Esophageal manometry, upper intestinal endoscopy, and autoantibody testing were performed.
- Abdominal pain was the primary symptom for referral.
Main Results:
- Six of eight breast-fed children exhibited abnormal esophageal motility, including reduced peristalsis and lower sphincter pressure.
- Bottle-fed infants exposed to silicone showed no such abnormalities.
- No significant differences in autoantibody expression were observed among groups.
Conclusions:
- A potential link exists between breast-feeding by mothers with silicone implants and abnormal esophageal motility in children.
- Larger studies are required to establish the risk and extent of this association.
Objective:
To determine whether breast-fed children of mothers with silicone implants are at increased risk for the development of sclerodermalike esophageal involvement compared with children not exposed to silicone implants.
Design:
Case-series [corrected].
Setting:
Referral-based pediatric gastroenterology clinic.
Patients:
Eleven children (mean age, 6.0 years; range, 1.5 to 13 years; six boys and five girls) referred for abdominal pain who were born to mothers who had silicone breast implants (eight breast-fed children and three bottle-fed) were compared with 17 patients (mean age, 10.7 years; range, 2 to 18 years; 11 boys and six girls) with abdominal pain who were not exposed to silicone implants.
Methods:
All children underwent esophageal manometry and upper intestinal endoscopy with esophageal biopsy and were tested for antinuclear antibody and autoantibodies to Scl-70, centromere, ribonucleoprotein, Sm, Ro, La, and phospholipid.
Results:
Six of the eight breast-fed children from mothers with silicone implants had significantly abnormal esophageal motility with nearly absent peristalsis in the distal two thirds of the esophagus and decreased lower sphincter pressure. Upper esophageal pressures and motility were normal. Compared with controls, the breast-fed children had significantly decreased lower sphincter pressure and abnormal esophageal wave propagation. These manometric abnormalities were not seen in the three bottle-fed children. There was no difference in the expression of autoantibodies in the breast-fed children compared with the bottle-fed children or controls.
Conclusions:
A relationship appears to exist between breast-feeding by mothers with silicone implants and abnormal esophageal motility. Studies evaluating larger numbers of children are needed to determine the extent of the risk.