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Related Experiment Videos

[The therapeutic measures in acute diffuse peritonitis]

V I Bondarev, N P Ablitsov, A P Baziak

    Klinicheskaia Khirurgiia
    |January 1, 1993
    PubMed
    Summary

    Intraabdominal lavage is recommended for acute diffuse peritonitis patients with moderate microcirculation changes. Hemosorption and lymphosorption show maximum effect within 3 days post-operation, improving outcomes.

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    Area of Science:

    • Surgical Gastroenterology
    • Peritoneal Disease Research
    • Microcirculation Studies

    Context:

    • Acute diffuse peritonitis presents significant clinical challenges.
    • Understanding microcirculatory changes in the parietal peritoneum is crucial for treatment.
    • 431 patient cases were analyzed to evaluate therapeutic interventions.

    Purpose:

    • To evaluate the efficacy of intraabdominal flowing lavage in acute diffuse peritonitis.
    • To determine optimal timing and indicators for applying hemosorption and lymphosorption.
    • To assess the overall lethality rate associated with the condition and treatments.

    Summary:

    • Intraabdominal flowing lavage is recommended for patients with inflammatory phenomena and moderately pronounced microcirculatory changes in the parietal peritoneum.
    • Maximum clinical effect of hemosorption and lymphosorption was observed within the first 3 days post-operation.
    • Optimal conditions for maximum effect include cathepsin-D activity of 14-17 activity units/(min·mg) and lymphorrhea exceeding 700 ml/day.
    • The observed lethality rate in this study cohort was 18.8%.

    Impact:

    • Provides evidence-based recommendations for intraabdominal lavage in specific peritonitis cases.
    • Identifies key biomarkers and timeframes for maximizing the benefits of hemosorption and lymphosorption.
    • Contributes to improving patient outcomes and potentially reducing mortality in acute diffuse peritonitis.

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