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Physostigmine: effects on cognition and affect in normal subjects

K L Davis, L E Hollister, J Overall

    Psychopharmacology
    |December 21, 1976
    PubMed
    Summary

    Physostigmine impairs short-term memory and causes a "physostigmine syndrome" of sedation and slowed thinking. Long-term memory consolidation remained unaffected, but some subjects experienced emotional distress.

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    Area of Science:

    • Neuroscience
    • Pharmacology

    Background:

    • Physostigmine is a reversible cholinesterase inhibitor.
    • Its effects on cognitive function and mood require further elucidation.

    Purpose of the Study:

    • To investigate the effects of physostigmine on short-term memory (STM) and long-term memory (LTM) consolidation.
    • To characterize the behavioral and emotional effects of physostigmine administration.

    Main Methods:

    • A double-blind, placebo-controlled study involving intravenous physostigmine (up to 3 mg) or saline.
    • Subjects received methscopolamine bromide subcutaneously prior to infusions.
    • Cognitive function was assessed using digit span tasks for STM and LTM consolidation.

    Main Results:

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  • A
  • physostigmine syndrome
  • characterized by decreased speech, slowed thoughts, sedation, and nausea, was observed at doses of 1.5-2.0 mg.
  • Physostigmine significantly impaired STM capacity compared to placebo.
  • No significant differences were found in LTM consolidation or overall mood, although two subjects in the physostigmine group became tearful and depressed.

    • Conclusions:

    • Physostigmine negatively impacts short-term memory and induces a distinct set of behavioral changes.
    • While not affecting long-term memory consolidation, physostigmine can precipitate negative emotional responses in some individuals.