Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Meniscal healing: a biomechanical study

K Roeddecker1, U Muennich, M Nagelschmidt

  • 1IInd Department of Surgery, University of Cologne, Germany.

The Journal of Surgical Research
|January 1, 1994
PubMed
Summary

Fibrin glue significantly improved scar strength in rabbit meniscus tears after six weeks compared to no treatment or sutures. This suggests fibrin glue is a promising therapy for repairing inner meniscus zones with poor healing capacity.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Laparoscopic live donor nephrectomy: Are ten cases per year enough to reach the quality standards? A report from a single small-volume transplant center.

Surgical endoscopy·2009
Same author

[The way to establish laparoscopic donor nephrectomy as the method of choice in live kidney donation--a single centre experience].

Zentralblatt fur Chirurgie·2008
Same author

Laparoscopic live donor nephrectomy for right kidneys: Experience in a German community hospital.

Surgical endoscopy·2007
Same author

Local administration of TGF-beta1 to reinforce the anterior abdominal wall in a rat model of incisional hernia.

Hernia : the journal of hernias and abdominal wall surgery·2005
Same author

[The technique of laparoscopic-thoracoscopic esophageal resection for esophageal cancer--first experiences].

Zentralblatt fur Chirurgie·2004
Same author

[Effect of pneumoperitoneum on plasminogen activator activity in the abdomen].

Langenbecks Archiv fur Chirurgie. Supplement. Kongressband. Deutsche Gesellschaft fur Chirurgie. Kongress·2003

Area of Science:

  • Orthopedic surgery
  • Biomedical engineering
  • Regenerative medicine

Background:

  • Meniscal tears, even in poorly vascularized areas, are increasingly targeted for repair.
  • Biomechanical testing in animal models provides data on scar strength after various therapies.
  • Understanding healing in avascular zones is crucial for effective meniscus repair.

Purpose of the Study:

  • To evaluate the biomechanical strength of scars in rabbit medial menisci after different repair methods.
  • To assess the impact of therapy on scar tissue and surrounding tissue integrity.
  • To compare the efficacy of no treatment, suture repair, and fibrin glue sealing.

Main Methods:

  • Standardized longitudinal lesions were created in the microvascular zone II of rabbit medial menisci.
  • Treated groups included no therapy, suture fixation, and fibrin glue sealing.
  • Tear load propagation tests were used to determine scar strength at 6 and 12 weeks.

Main Results:

  • After 6 weeks, scar strength was 19% (no therapy), 26% (suture), and 42.5% (fibrin glue) of intact controls.
  • Fibrin glue treatment resulted in a shorter zone of secondary tissue weakness compared to other groups.
  • At 12 weeks, scar strength remained similar, but the area of tissue weakness decreased, especially with fibrin glue.

Conclusions:

  • Fibrin glue demonstrates superior biomechanical outcomes in rabbit meniscus repair compared to sutures or no treatment.
  • The findings suggest fibrin glue is a viable option for clinical studies on meniscus repair in avascular zones.
  • Further long-term studies are needed to fully assess ultimate scar strength and healing potential.

Related Experiment Videos