[Evaluation of the hepatitis B prevention program in newborn infants. I. National data, 1990]

P M Grosheide¹, A L den Ouden, G H Verrips

¹Centrum voor Infectieziekten Epidemiologie, Rijksinstituut voor Volksgezondheid en Milieuhygiëne, Bilthoven.

Nederlands Tijdschrift Voor Geneeskunde

|December 11, 1993

Abstract

Objective:

To evaluate the effectiveness of the national programme for prevention of perinatal hepatitis B infections.

Setting:

The regional public health laboratories and provincial immunization administrations in the Netherlands.

Design:

Retrospective evaluation.

Methods:

Starting October 1989 routine screening of pregnant women for HBsAg was performed and passive-active immunisation of infants of HBsAg-positive mothers was added to the national immunisation programme. Infants receive hepatitis B immunoglobulin at birth and hepatitis B vaccine at 3,4,5, and 11 months of age, concomitant with the DTP-polio vaccine. The effectiveness of screening and intervention in 1990 was evaluated.

Results:

Screening covered about 85% of the pregnant population and the prevalence (0.44%) was less than expected. About 60% of the infants born to HBsAg-positive mothers were registered for vaccination. Of these infants the average coverage was 83% for immunoglobulin, and 90%, 86%, 80% and 55% for the four successive hepatitis B vaccinations. There was considerable delay in vaccine administration; frequently doses were administered later than recommended.

Conclusion:

Compliance with screening and vaccination appeared incomplete. Recommendations for the simplification of the current programme are made.

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Objective:

Setting:

Design:

Methods:

Results:

Conclusion:

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