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Preimplantation prenatal diagnosis

K D McGowan1

  • 1Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Obstetrics and Gynecology Clinics of North America
|September 1, 1993
PubMed
Summary

Preimplantation prenatal diagnosis uses molecular genetic techniques to assess gametes or embryos before implantation. This allows at-risk couples to achieve pregnancies free from specific genetic disorders using assisted reproductive technology.

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Area of Science:

  • Reproductive Medicine
  • Clinical Genetics
  • Embryology

Background:

  • Couples at significant risk for genetic diseases face challenges in conceiving unaffected offspring.
  • Assisted reproductive technology (ART) offers potential solutions for family planning in these cases.

Purpose of the Study:

  • To describe preimplantation prenatal diagnosis (PPD) techniques.
  • To review the risks, benefits, limitations, and applications of PPD.
  • To summarize recent human pregnancy experiences with PPD.

Main Methods:

  • Application of molecular genetic techniques for assessing gametes and early embryos.
  • Utilizing assisted reproductive technology for embryo selection prior to implantation.

Main Results:

  • PPD enables the identification of embryos free from specific genetic disorders.
  • Recent human pregnancies demonstrate the feasibility of PPD.

Conclusions:

  • Preimplantation prenatal diagnosis is a viable option for couples seeking to avoid passing on genetic diseases.
  • PPD offers hope for unaffected pregnancies in families with a history of genetic disorders.

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