Some toxicological issues in chemical safety and regulation in an Australian context

This article considers the potential effects on the human body of toxic hazardous substances in general, along with advanced methods of detecting short- and long-term effects of exposure with reference to the results of recent research. In addition to occupational exposure, other contributors to an individual's overall toxic exposure load including environmental and home and lifestyle exposures are also considered in detail. Toxicological information (from diverse sources) and an awareness of the limitations of our present state of knowledge of toxicology are concluded to be important factors in developing chemical safety and regulatory criteria. Although there is some debate concerning the adequacy of the exposure standard-setting process, TWA measures are capable of giving reliable indications of the efficacy of control measures and procedures. Electroencephalogram (EEG) activity reflecting stimulus attention and decision time, electromyography measuring nerve conduction velocities, reaction time, and neuropsychological performance-using batteries of psychometric tests, may all be effective indicators of exposure, interaction with other factors, and long-term effects of exposure.