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Phagocytic activity in stressed mice: effects of alprazolam
M Freire-Garabal1, M J Núñez, J C Fernández-Rial
1Neuroimmunology University of Santiago (NIMUS), Hospital Médico-Quirúrgico de Conxo, Santiago de Compostela, Spain.
Research in Immunology
|June 1, 1993
Abstract:
Mice exposed to a chronic auditory stressor and daily injected with alprazolam (1 mg/kg/day, s.c.) showed a reduction in stress-induced suppression of the in vitro and in vivo activity of phagocytosis, measured using the zymosan particle uptake method and the carbon clearance test, respectively. Pretreatment with Ro-15-1788 (10 mg/kg, s.c.), a central nervous system benzodiazepine antagonist, resulted in suppression of the effects of alprazolam in stressed mice.