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Related Experiment Videos

Effects of selenium status on bovine mononuclear cell function

L M Sordillo1, C R Hicks, R Wilson

  • 1Department of Veterinary Science, Pennsylvania State University 16802-3500.

Zentralblatt Fur Veterinarmedizin. Reihe A
|October 1, 1993
PubMed
Summary

Selenium deficiency in dairy cows reduced circulating monocytes but did not impact lymphocyte function or immune response. This suggests selenium

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Area of Science:

  • Animal immunology
  • Nutritional biochemistry
  • Dairy cattle health

Background:

  • Selenium (Se) is an essential trace element crucial for immune function.
  • Understanding Se's role in bovine immunity is vital for dairy herd health.
  • Peripheral blood mononuclear cells (PBMC) are key players in cellular immunity.

Purpose of the Study:

  • To investigate the impact of selenium status on bovine PBMC distribution and function.
  • To determine if Se deficiency affects lymphocyte proliferation, IL-2 production, or trafficking.
  • To assess the influence of Se on monocyte numbers and their accessory functions.

Main Methods:

  • Comparison of PBMC from dairy cows fed Se-adequate versus Se-deficient diets.
  • Assays for mitogen-induced proliferation and interleukin-2 (IL-2) production.
  • Analysis of IL-2 receptor expression and lymphocyte trafficking patterns.
  • Quantification of circulating monocyte populations and assessment of antigen presentation capabilities.

Main Results:

  • No significant differences in lymphocyte proliferation, IL-2 production, or IL-2 receptor expression were found between Se-adequate and Se-deficient groups.
  • Selenium deficiency led to a significant reduction in circulating monocyte numbers.
  • Reduced monocyte counts did not impair antigen presentation or IL-2 production by these cells.

Conclusions:

  • Bovine peripheral blood mononuclear cell function, particularly lymphocyte responses, is not significantly altered by selenium deficiency.
  • Selenium deficiency primarily impacts monocyte populations in circulation.
  • The effects of Se-modified diets on bovine immune defense are not mediated through altered lymphocyte immunocompetence.

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