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Related Experiment Videos

Possible variation in bone resorption during the normal menstrual cycle

A Schlemmer1, C Hassager, J Risteli

  • 1Department of Clinical Chemistry, Glostrup Hospital, University of Copenhagen, Denmark.

Acta Endocrinologica
|November 1, 1993
PubMed
Summary

Bone turnover markers show slight menstrual cycle variations. Serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (sICTP) peaked in the luteal phase, while bone formation markers remained constant in premenopausal women.

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Area of Science:

  • Endocrinology
  • Bone Metabolism
  • Reproductive Biology

Background:

  • Bone turnover is a continuous process regulated by hormones.
  • The menstrual cycle involves significant hormonal fluctuations.
  • Understanding bone turnover dynamics during the menstrual cycle is crucial for women's health.

Purpose of the Study:

  • To investigate potential variations in bone turnover during the normal menstrual cycle.
  • To assess specific biochemical markers of bone resorption and formation.

Main Methods:

  • Ten healthy premenopausal women participated.
  • Biochemical markers of bone resorption and formation were measured every 2-3 days throughout a complete menstrual cycle.
  • Markers included serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (sICTP), urinary hydroxyproline/creatinine, urinary pyridinoline/creatinine, urinary deoxypyridinoline/creatinine, plasma osteocalcin, serum carboxy-terminal propeptide of type I procollagen, and serum alkaline phosphatase.

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Main Results:

  • A cyclic pattern was observed in sICTP, with levels lowest in the follicular phase and highest in the luteal phase (17% variation, p=0.004).
  • No significant cyclic changes were detected in urinary bone resorption markers.
  • Biochemical markers of bone formation remained constant throughout the menstrual cycle.

Conclusions:

  • Serum pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen (sICTP) exhibits minor fluctuations during the normal menstrual cycle in premenopausal women.
  • Established biochemical markers of bone formation do not show cyclic variations.
  • sICTP may serve as a sensitive indicator of subtle bone turnover changes related to the menstrual cycle.