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Combination effect on HIV infection in vitro of soluble CD4 and HIV-neutralizing antibodies
J E Hansen1, A M Sørensen, S Olofsson
1Laboratory for Infectious Diseases, Hvidovre Hospital, Denmark.
Archives of Virology
|January 1, 1994
In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic neutralizing effect on HIV infection. However, sCD4 and an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.
In combination with HIV gp120 V3-loop antibody, two carbohydrate specific neutralizing antibodies (83D4 and 2G12) had a synergistic neutralizing effect on HIV infection. However, sCD4 and an antibody which blocks gp 120/CD4 binding (1B1) both displayed antagonism.