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Contrast sensitivity function in Graves' ophthalmopathy and dysthyroid optic neuropathy
M S Suttorp-Schulten1, R Tijssen, M P Mourits
1Netherlands Ophthalmic Research Institute, Amsterdam.
The British Journal of Ophthalmology
|November 1, 1993
Summary
Contrast sensitivity is impaired in dysthyroid optic neuropathy and Graves' ophthalmopathy. Dysthyroid optic neuropathy specifically shows reduced sensitivity at low spatial frequencies, aiding in diagnosis.
Area of Science:
- Ophthalmology
- Neuro-ophthalmology
- Medical Imaging
Background:
- Graves' ophthalmopathy (GO) is an autoimmune condition affecting the thyroid and eyes.
- Dysthyroid optic neuropathy (DON) is a sight-threatening complication of GO.
- Contrast sensitivity is a crucial visual function often affected in ocular diseases.
Purpose of the Study:
- To compare contrast sensitivity function (CSF) in patients with DON and GO.
- To differentiate between DON and GO using CSF measurements.
- To establish normative CSF data for healthy controls.
Main Methods:
- Computer automated method used for CSF measurement.
- Study included 38 eyes with DON, 34 eyes with GO only, and 74 healthy control eyes.
- Analysis focused on CSF across different spatial frequencies.
Main Results:
- Both DON and GO groups exhibited significant disturbances in CSF compared to controls.
- DON group showed a pronounced loss of contrast sensitivity in the low spatial frequency range.
- This low-frequency deficit in DON was a key differentiator from the GO-only group.
Conclusions:
- CSF is significantly impaired in both DON and GO.
- Measurement of CSF, particularly at low spatial frequencies, can help differentiate DON from GO.
- Automated CSF testing offers a valuable tool for diagnosing and managing thyroid eye disease complications.