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Possible myocardial toxicity associated with interleukin-4 therapy
E G Trehu1, J M Isner, J W Mier
1Department of Medicine, New England Medical Center, Boston, MA 02111.
Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy
|November 1, 1993
Summary
High-dose Interleukin-4 (IL-4) therapy may cause myocarditis, an inflammation of the heart muscle. This study identified a unique inflammatory pattern in a melanoma patient, suggesting potential cardiac risks associated with IL-4 treatment.
Area of Science:
- Immunology
- Oncology
- Cardiology
Background:
- Interleukin-4 (IL-4) is a cytokine produced by T lymphocytes.
- IL-4 influences allergic inflammation by stimulating immunoglobulin E production and mast cells.
- The cardiac effects of IL-4 therapy are not well-established.