Hair cell overproduction in the developing mammalian cochlea in culture

Hair cells transduce acoustics into electrical signals that are conveyed to the brain by auditory nerve fibres. Hair cells loss in mammals due to ageing, ototoxic drugs or noise, leads to irreversible hearing impairment. One objective would be to replace lost cells by regeneration or production of new hair cells. We report an overproduction of hair cells in the developing cochlea of the rat in culture without adding drugs, without previous injury or special manipulations of the explants. The overproduction of hair cells does not depend on the culture medium or on the innervation of the organ of Corti. Younger foetal explants show higher potency for the production of supplementary hair cells than older ones. This is the first report of the generation of extra hair cells in mammals without previous hair cell loss or treatment with drugs.