Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conjoined twins: implications for blastogenesis

G A Machin1

  • 1Department of Pathology, University of Alberta, Edmonton, Canada.

Birth Defects Original Article Series
|January 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Congenital heart defects in a large, unselected cohort of monochorionic twins.

Journal of perinatology : official journal of the California Perinatal Association·2012
Same author

The monochorionic twin placenta in vivo is not a black box.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology·2001
Same author

Zygosity of twins: is it time for a new terminology?

Ginekologia polska·2001
Same author

[Peculiarities of multiple pregnancy: embryology].

Ginekologia polska·2001
Same author

[Peculiarities of multiple pregnancy: diagnosis].

Ginekologia polska·2001
Same author

[Peculiarities of multiple pregnancy: complications].

Ginekologia polska·2001
Same journal

A case of short-rib syndrome without polydactyly in a stillborn: a new type?

Birth defects original article series·1996
Same journal

Hand malformations in the aborted embryo: an important source of genetic information.

Birth defects original article series·1996
Same journal

Colophon: on doing morphology.

Birth defects original article series·1996
Same journal

Congenital eye malformations: a descriptive epidemiologic study in about one million newborns in Italy.

Birth defects original article series·1996
Same journal

CHARGE association in a neonate exposed in utero to carbon monoxide.

Birth defects original article series·1996
Same journal

Fetal valproate embryopathy in twins: genetic modification of the response to a teratogen.

Birth defects original article series·1996
See all related articles

This study classifies conjoined twins (CT) into main anatomic types based on notochordal arrangements. Understanding these patterns helps explain organ development and malformations in CT embryogenesis.

Area of Science:

  • Developmental Biology
  • Embryology
  • Teratology

Background:

  • Conjoined twins (CT) present complex developmental anomalies.
  • Limited well-documented cases hinder broad conclusions on CT blastogenesis.

Purpose of the Study:

  • To propose classifications and propose conclusions regarding the blastogenesis of conjoined twins.
  • To elucidate the role of notochordal axes and their arrangements in CT development.

Main Methods:

  • Analysis of reported anatomical types of conjoined twins.
  • Deduction of embryonic disc axis orientations from resulting anatomy.
  • Examination of organogenesis and tissue development in various CT types.

Main Results:

Related Experiment Videos

  • Most CT fit into a few main anatomic types with transitional forms.
  • CT typically possess two notochordal axes, with ventral organs potentially malformed.
  • New ventro-lateral axes form due to space constraints, representing organizational events.
  • Axis orientations are usually end-on or ventro-ventral, except in dicephalus.
  • Specific CT types like diprosopus, cephalothoracopagus, thoracopagus, and ischiopagus exhibit distinct developmental patterns.
  • Interaction aplasia and cardiovascular malformations are observed due to developmental conflicts.

    • Conclusions:

    • CT can be classified based on notochordal arrangements, aiding understanding of embryogenesis.
    • Notochordal axes and their spatial orientation are critical in shaping CT anatomy.
    • Further study of specific CT types like diprosopus can clarify notochordal forking.
    • Developmental interactions, axis formation, and organogenesis variations explain CT phenotypes.