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Mild de Lange syndrome--does it exist?
M Baraitser1, A S Papavasiliou
1Department of Clinical Genetics, Hospital for Sick Children, London, UK.
Clinical Dysmorphology
|April 1, 1993
Abstract:
A pair of mildly retarded, microcephalic twins (probably identical) are reported. They were initially diagnosed as having the de Lange syndrome on the basis of the synophrys, but, on follow-up, their main intellectual defect was in the area of expressive speech. It is suggested that the evidence in the literature for the existence of so-called mild de Lange is sparse and that the twins in this report might well have a different, possibly unique condition.