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Clonidine does not affect lidocaine seizure threshold in rats
M Yokoyama1, M Hirakawa, H Goto
1Department of Anesthesiology and Resuscitology, Okayama University Medical School, Japan.
Canadian Journal of Anaesthesia = Journal Canadien D'Anesthesie
|December 1, 1993
Summary
Clonidine did not alter the dose of lidocaine needed to cause convulsions in rats. However, clonidine did affect lidocaine
Area of Science:
- Pharmacology
- Neuroscience
- Toxicology
Background:
- Lidocaine is a local anesthetic with a narrow therapeutic index.
- High doses of lidocaine can cause central nervous system toxicity, including convulsions.
- Clonidine is an alpha-2 adrenergic agonist with potential central nervous system effects.
Purpose of the Study:
- To investigate the effect of clonidine on lidocaine-induced convulsions and hemodynamic changes in rats.
- To determine if clonidine possesses anticonvulsant or proconvulsant properties against lidocaine toxicity.
- To examine the combined effects of clonidine and lidocaine on cardiovascular parameters.
Main Methods:
- Wistar rats were pretreated with intravenous clonidine or saline.
- Lidocaine was infused intravenously until generalized convulsions occurred.
- Cumulative convulsant doses, plasma lidocaine concentrations, mean arterial blood pressure, and heart rate were measured.
Main Results:
- Clonidine pretreatment did not alter the cumulative convulsant dose or plasma lidocaine concentration at the onset of convulsions.
- Clonidine significantly decreased mean arterial blood pressure and heart rate.
- The combination of clonidine and lidocaine potentiated the bradycardic effect of lidocaine.
Conclusions:
- Clonidine does not exhibit anticonvulsant or proconvulsant effects on lidocaine-induced convulsions.
- Clonidine significantly impacts hemodynamic parameters, and its interaction with lidocaine warrants further investigation.
- The cardiovascular effects of combining clonidine and lidocaine require additional study.