Jove
Visualize
Contact Us

Related Experiment Videos

Rheumatic fever and the HLA complex. A cosegregation study

M Gerbase-DeLima1, L C Scala, J Temin

  • 1Department of Pediatrics, Escola Paulista de Medicina, Universidade Federal de Mato Grosso, São Paulo, Brazil.

Circulation
|January 1, 1994
PubMed
Summary

Genetic analysis suggests a dominant inheritance pattern for rheumatic fever (RF) susceptibility. A gene linked to RF risk may be located within or near the human leukocyte antigen (HLA) complex.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

HLA-B*15:04:04, a novel HLA allele identified during proficiency testing in Brazil.

HLA·2016
Same author

Seroprevalence of Brucella ovis in rams and associated flock level risk factors in the state of Rio Grande do Sul, Brazil.

Preventive veterinary medicine·2015
Same author

Reduced Incidence of Cytomegalovirus Infection in Kidney Transplant Recipients Receiving Everolimus and Reduced Tacrolimus Doses.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2015
Same author

The HLA-A*02:481 allele was identified in unrelated Brazilians sharing HLA-B*15:17, C*07:01P, DRB1*13:02 and DQB1*06:04.

Tissue antigens·2014
Same author

Minor H antigen matches and mismatches are equally distributed among recipients with or without complications after HLA identical sibling renal transplantation.

Tissue antigens·2013
Same author

Algorithms for the determination of unacceptable HLA antigen mismatches in kidney transplant recipients.

Tissue antigens·2013
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Immunogenetics
  • Rheumatology

Background:

  • Controversial findings exist regarding human leukocyte antigen (HLA) associations with rheumatic fever (RF).
  • Previous studies have yielded conflicting results on the role of HLA genes in RF susceptibility.

Purpose of the Study:

  • To investigate the involvement of HLA genes in RF susceptibility using cosegregation analysis.
  • To clarify the genetic basis of RF by examining HLA gene linkage.

Main Methods:

  • Cosegregation analysis was performed on 22 genetically informative families.
  • Identical-by-descent (IBD) HLA haplotype sharing was compared between affected individuals and controls.
  • Statistical tests (chi-squared goodness-of-fit) were employed to assess segregation patterns.

Main Results:

Related Experiment Videos

  • Analysis of 51 affected and 66 healthy individuals suggested a trend (P = .088) for HLA involvement.
  • Further analysis in affected sib pairs rejected a recessive inheritance model for RF susceptibility genes.
  • A dominant mode of inheritance with high penetrance (0.5-0.9) and low susceptibility gene frequency (≥1%) was supported.

Conclusions:

  • The study provides evidence supporting an RF susceptibility gene within or near the HLA complex.
  • The findings suggest a dominant genetic component in RF pathogenesis linked to HLA.