Plasma enteroglucagon levels in different models of intestinal resection in the rat

To assess the influence of the different intestinal segments on the plasma enteroglucagon level, three models of intestinal resection in the rat were studied (jejunal, ileal, 90%). The basal values for this peptide and those obtained after an infusion of intraduodenal glucose were compared. The results obtained in basal/post-glucose infusion were: 50% proximal (jejunum): 220/728 pg/ml; 50% distal (ileum): 10/233 pg/ml; and the middle 90%: 108/297 pg/ml. The glucose infusion produced a maximal response, permitting a better evaluation of the differences among the three resection models. The highest levels corresponded to the group in which the entire ileum was conserved.