Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Basic mechanisms of cardiac gene expression

B Nadal-Ginard1, V Mahdavi

  • 1Laboratory of Molecular and Cellular Cardiology, Howard Hughes Medical Institute, Boston, MA.

European Heart Journal
|November 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lethal and Demographic Impact of Chlorpyrifos and Spinosad on the Ectoparasitoid Habrobracon hebetor (Say) (Hymenoptera: Braconidae).

Neotropical entomology·2015
Same author

Resident cardiac stem cells.

Cellular and molecular life sciences : CMLS·2007
Same author

Hyperglycemia activates p53 and p53-regulated genes leading to myocyte cell death.

Diabetes·2001
Same author

Mobilized bone marrow cells repair the infarcted heart, improving function and survival.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same author

Oxidative stress-mediated cardiac cell death is a major determinant of ventricular dysfunction and failure in dog dilated cardiomyopathy.

Circulation research·2001
Same author

Telomerase expression and activity are coupled with myocyte proliferation and preservation of telomeric length in the failing heart.

Proceedings of the National Academy of Sciences of the United States of America·2001
Same journal

Great debate: medical treatment of heart failure with reduced ejection fraction will rely on four foundational drugs.

European heart journal·2026
Same journal

The surgical collateralization theory: has the beautiful hypothesis been killed by the ugly facts?

European heart journal·2026
Same journal

Beyond single measurement: additional considerations for high-sensitivity C-reactive protein in cardiovascular risk prediction.

European heart journal·2026
Same journal

Brain mineralocorticoid receptor activation and antagonism in heart failure with preserved ejection fraction: a hypothesis.

European heart journal·2026
Same journal

Myths and misconceptions about high-sensitivity C-reactive protein as a marker of residual inflammatory risk.

European heart journal·2026
Same journal

Vascular Ehlers-Danlos syndrome: should we treat asymptomatic patients?

European heart journal·2026
See all related articles

Molecular and cell biology advancements have illuminated the biochemical basis of cardiac development and performance. These breakthroughs enable detailed gene expression analysis and offer potential for cardiovascular gene therapy.

Area of Science:

  • Cardiovascular Physiology
  • Molecular Biology
  • Biochemistry

Background:

  • Physiological properties of the myocardium extensively studied for decades.
  • Biochemical and molecular basis of cardiac development and performance were poorly understood.
  • Modern molecular biology tools are now available to study these mechanisms.

Purpose of the Study:

  • To understand the mechanisms involved in cardiac development.
  • To elucidate the basis for clinical and experimental problems in cardiovascular physiology.
  • To explore the practical applications of molecular biology in cardiology.

Main Methods:

  • Cloning and characterization of genes encoding contractile proteins.
  • Utilizing molecular probes for gene analysis.

Related Experiment Videos

  • Introducing genes into specific cell types and tissues in living animals.
  • Analyzing gene expression through direct gene injection in physiologically relevant contexts.

    • Main Results:

    • Significant breakthroughs in molecular and cell biology provide tools for cardiac research.
    • Enables analysis of basic gene expression mechanisms.
    • Facilitates identification of regulatory gene sequences and transactive factors.
    • Allows study of gene expression in natural, controllable, and physiologically relevant conditions.

    Conclusions:

    • Molecular and cell biology have revolutionized the study of cardiac development and performance.
    • These advancements are crucial for understanding cardiovascular physiology.
    • Direct gene injection offers a powerful method for studying gene expression in vivo.
    • Potential applications for gene therapy in cardiovascular medicine are significant.