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Updated: Aug 7, 2026

Expression Analysis of Mammalian Linker-histone Subtypes
Published on: March 19, 2012
Structural study of rat thyroid transcription factor 1 homeodomain (TTF-1 HD) by nuclear magnetic resonance
P Viglino1, F Fogolari, S Formisano
1Dipartimento di Scienze e Technologie Biomediche, Università di Udine, Italy.
Abstract:
The 500 MHz 1H NMR spectrum of a 68-residue peptide, encompassing the rat thyroid transcription factor 1 homeodomain (TTF-1 HD), was fully assigned using standard 2D NMR methodology. The secondary structure elements and their spatial organization were determined and led to a structure very similar to that previously described for other homeodomains and expected also for TTF-1 HD from homology modeling predictions. The three-dimensional arrangement of the three helix fragments of TTF-1 HD preserves the helix-turn-helix motif commonly occurring in many classes of DNA-binding proteins.
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