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Isosexual precocity: the clinical and etiologic profile
M Desai1, M P Colaco, C S Choksi
1Division of Pediatric Endocrinology, Bai Jerbai Wadia Hospital for Children, Bombay.
Indian Pediatrics
|May 1, 1993
Summary
This study investigated 80 children with precocious puberty, finding true precocious puberty (TPP) in 50%. Etiologies varied, with central causes like tubercular meningitis more common in girls and adrenal issues prevalent in boys.
Area of Science:
- Pediatric Endocrinology
- Reproductive Health
- Child Development
Background:
- Isosexual precocity, or early puberty, affects children's physical and psychological well-being.
- Identifying the underlying cause is crucial for appropriate management and treatment.
Purpose of the Study:
- To clinically evaluate and investigate the etiologies of isosexual precocity in a cohort of 80 children.
- To differentiate between central and peripheral causes of precocious puberty.
Main Methods:
- Clinical evaluation and diagnostic investigations were performed on 80 children presenting with isosexual precocity.
- Hormonal assays (LH, estradiol, LH/FSH ratio) and imaging were utilized to determine the cause.
Main Results:
- True precocious puberty (TPP) was diagnosed in 50% of children (29 girls, 11 boys).
- In girls, idiopathic TPP (ITPP) was less frequent (52%) than neurogenic TPP (NTTP, 48%), with tubercular meningitis a significant cause (31%).
- In boys, NTTP (73%) was more common than ITPP (27%), with hamartomas and tubercular meningitis equally contributing. Adrenal and testicular causes accounted for 41% of precocity in boys.
Conclusions:
- The etiologies of isosexual precocity are diverse, with central causes like TPP being significant in both genders.
- Neurogenic causes, particularly tubercular meningitis, are notable in this cohort, differing from Western series.
- Adrenal and testicular pathologies are important considerations in the differential diagnosis of precocious puberty in boys.