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Coronary vasospasm, multiple coronary thrombosis, unstable angina and essential thrombocytosis
1Department of Internal Medicine, Inha University Hospital, Kyunggi-do, South Korea.
Insights
Essential thrombocythemia can rarely cause coronary artery occlusion. This case highlights coronary vasospasm and thrombosis in a patient with essential thrombocythemia, migraine, and Raynaud's phenomenon.
Area of Science:
- Cardiology
- Hematology
- Vascular Medicine
Background:
- Essential thrombocythemia (ET) is a myeloproliferative neoplasm characterized by elevated platelet counts.
- ET is associated with an increased risk of thrombotic and hemorrhagic complications.
- Coronary artery occlusion is a rare but serious manifestation of ET.
Observation:
- This report details a unique case of a woman experiencing coronary vasospasm and multiple coronary thromboses.
- The patient presented with symptoms suggestive of myocardial infarction and unstable angina pectoris.
- She had a medical history of migraine and Raynaud's phenomenon, in addition to essential thrombocytosis.
Findings:
- Coronary angiography revealed extensive thrombosis involving both the right and left coronary arteries.
- The findings suggest a potential link between ET, vasospastic disorders, and severe coronary events.
- This presentation is distinct from previously reported cases of ET-associated coronary artery occlusion.
Implications:
- This case underscores the importance of considering coronary artery thrombosis in patients with ET, especially those with concurrent vasospastic conditions.
- Early recognition and management of thrombotic events in ET patients are crucial for preventing adverse cardiovascular outcomes.
- Further research may elucidate the mechanisms underlying coronary thrombosis in ET and its association with vasospasm.
Abstract:
Rarely, essential thrombocythemia has led to coronary artery occlusion. Only one patient has been described, in whom coronary angiography demonstrated multiple coronary thrombosis. We report a case of coronary vasospasm, multiple coronary thrombosis involving right and left coronary artery and possibly leading to myocardial infarction and unstable angina pectoris in a woman with migraine, Raynaud's phenomenon, and essential thrombocytosis.