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Lactate release from the subcutaneous tissue in lean and obese men
P A Jansson1, A Larsson, U Smith
1Department of Internal Medicine, University of Göteborg, Sahlgren's Hospital, Sweden.
The Journal of Clinical Investigation
|January 1, 1994
Summary
Subcutaneous adipose tissue releases significant lactate in fasting individuals, with obese men showing enhanced release due to larger fat mass. Lactate levels increase post-glucose, but only lean men show a significant rise in lactate release.
Area of Science:
- Metabolism
- Endocrinology
- Human Physiology
Background:
- Subcutaneous adipose tissue's role in systemic lactate metabolism is not fully elucidated.
- Understanding lactate dynamics in adipose tissue is crucial for metabolic health assessment, particularly in obesity.
Purpose of the Study:
- To quantify lactate release from subcutaneous adipose tissue in lean and obese men.
- To investigate the impact of fasting and glucose load on adipose tissue lactate metabolism.
- To compare interstitial lactate levels with plasma lactate concentrations.
Main Methods:
- Simultaneous measurement of interstitial lactate and adipose tissue blood flow (ATBF) using microdialysis and 133Xe clearance.
- Studies conducted in abdominal and femoral subcutaneous adipose tissue in lean and obese men.
- Measurements performed in postabsorptive state and 2 hours after oral glucose load, with comparisons to arterialized venous plasma lactate.
Main Results:
- Interstitial lactate levels were significantly higher than plasma lactate in both lean and obese subjects.
- Obese men exhibited higher arterial lactate levels compared to lean men in the fasting state.
- While both groups showed increased lactate post-glucose, only lean men demonstrated a significant increase in apparent lactate release from adipose tissue.
Conclusions:
- Subcutaneous adipose tissue is a significant contributor to whole-body lactate release in the postabsorptive state.
- Lactate release from adipose tissue appears to be enhanced in obese individuals, likely due to their larger adipose tissue mass.
- The response of adipose tissue lactate release to a glucose load differs between lean and obese individuals.
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