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Enhanced detection of brain tumors by [18F]fluorodeoxyglucose PET with glucose loading
K Ishizu1, N Sadato, Y Yonekura
1Department of Nuclear Medicine, Faculty of Medicine, Kyoto University, Japan.
Objective:
We applied glucose loading during PET studies with [18F]2-fluoro-2-deoxy-D-glucose (FDG) to enhance detection of brain tumors by diminution of FDG uptake in normal gray matter.
Materials And Methods:
This study involved three patients with glioblastomas. Two PET scans were performed in all cases within 1 week in control and with glucose loading state.
Results:
In all patients, tumor was depicted more clearly with glucose loading than in the control study. The FDG uptake ratio of tumor to normal cortical gray matter showed a mean increase of 27% with glucose loading.
Conclusion:
This technique might be useful for detection of recurrent or residual tumors.