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Endogenous digoxin-like factor in acute myocardial infarction
A Y Bagrov1, E A Kuznetsova, O V Fedorova
1Division of Cardiology, I. I. Dzhanelidze Research Institute of Emergency Medicine, St Petersburg, Russian Federation.
Journal of Internal Medicine
|January 1, 1994
Summary
Plasma levels of endogenous digoxin-like factor (EDLF) increase one day after acute myocardial infarction (AMI). Higher EDLF concentrations may be linked to ventricular arrhythmias in AMI patients.
Area of Science:
- Cardiology
- Biochemistry
Background:
- Endogenous digoxin-like factor (EDLF) is a substance found in the body that shares similarities with the cardiac glycoside digoxin.
- Its role in cardiovascular conditions, particularly after acute myocardial infarction (AMI), requires further investigation.
Purpose of the Study:
- To investigate the changes in plasma concentrations of EDLF in the early period following AMI.
- To determine if elevated EDLF levels are associated with the occurrence of ventricular arrhythmias in AMI patients.
Main Methods:
- A consecutive sample study involving 54 patients with first transmural AMI, 16 with unstable angina pectoris, and 8 healthy controls.
- Plasma EDLF concentrations were measured using DELFIA digoxin fluoroimmunoassay during days 1-14 post-AMI.
- Analysis included uncomplicated AMI, AMI with ventricular fibrillation, and AMI with congestive heart failure.
Main Results:
- Plasma EDLF levels were significantly increased on day 1 post-AMI compared to controls and unstable angina patients.
- Higher EDLF concentrations were observed in AMI patients who experienced ventricular fibrillation.
- Conversely, EDLF levels were lower in AMI patients with congestive heart failure.
Conclusions:
- Plasma EDLF concentrations rise during the first day after AMI.
- Elevated EDLF levels may be associated with the development of ventricular arrhythmias following AMI.