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Oncogenes, tumor suppressors and viruses in oral squamous carcinoma
1University Department of Oral Medicine, Pathology and Microbiology, Bristol Dental Hospital and School, England.
Abstract:
The pathogenesis of oral squamous cell carcinoma involves recognised carcinogens in tobacco and/or alcohol but other factors, including viruses, may also have a role. This paper reviews the gene changes revealed in oral carcinoma, the evidence implicating viruses, and mechanisms whereby viruses may affect gene function.