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[Congenital candida infections]

R L Schlösser1, A Zubcov, M Bollinger

  • 1Abteilung Neonatologie, Johann-Wolfgang-Goethe-Universität, Frankfurt/Main.

Monatsschrift Kinderheilkunde : Organ Der Deutschen Gesellschaft Fur Kinderheilkunde
|November 1, 1993
PubMed
Summary

Congenital Candida infection, though rare, can occur during pregnancy. Risk factors include intrauterine devices, with severity depending on gestational age, impacting premature infants significantly.

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Area of Science:

  • Medical Mycology
  • Neonatal Infections
  • Obstetrics

Background:

  • Congenital Candida infection is a rare but serious condition.
  • High incidence of Candida vaginitis during pregnancy poses a risk.
  • Understanding risk factors and pathogenesis is crucial for prevention and treatment.

Observation:

  • Five cases of congenital Candida infection are presented.
  • Infection can occur with intact fetal membranes, causing chorioamnionitis.
  • Intrauterine devices (IUDs) are identified as a risk factor.

Findings:

  • Pathogenesis depends on gestational age, with premature infants at higher risk.
  • Candida endophthalmitis in a premature infant was successfully treated with intravenous Fluconazole.

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  • Systemic and cutaneous candidiasis were observed in other infants with varying severity.

    • Implications:

    • Early recognition and management are vital for improving outcomes in congenital Candida infections.
    • Identifying IUDs as a risk factor can guide preventative strategies.
    • Gestational age is a critical determinant of disease severity and prognosis.