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Dose-response relationship of atracurium besylate in the halothane-anaesthetised pig

G D Shorten¹, N M Gibbs

¹Department of Anaesthesia, Sir Charles Gairdner Hospital, Nedlands, Western Australia.

Research in Veterinary Science

|November 1, 1993

Abstract:

The dose response relationship for the intermediate-acting non-depolarising muscle relaxant, atracurium besylate in the pig was determined using evoked electromyography. An incremental dose technique was used in seven Large White/Landrace crossbred pigs anaesthetised with nitrous oxide and halothane. ED50 and ED95 were 510 +/- 87 micrograms kg-1 and 1150 +/- 270 micrograms kg-1, respectively. Although these values may represent an overestimate, they provide a reasonable guideline for the use of atracurium by veterinary anaesthetists.

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