[Effect of ethanol and lipid peroxidation on testosterone biosynthesis by interstitial cells of rat testes]

The induction of lipid peroxidation in interstitial cells of rat testes of ADP-Fe3+ complex results in the decrease of testosterone biosynthesis. Ethanol at 50 mM concentration enhances the level of malonic dialdehyde and inhibits the steroidogenesis. Effects of alcohol and ADP-Fe3+ complex both on lipid peroxidation or testosterone biosynthesis are additive. This agrees with the idea about the mediation of ethanol effects in testes by the induction of lipid peroxidation.