[Resistance to diuretic therapy]

Sequential nephron blockade--the combination of several diuretic agents which inhibit sodium reabsorption at different nephron sites simultaneously--is an effective, but potentially dangerous means of treating resistant edema. Several drug combinations have been used successfully, especially they have included a loop diuretic (furosemide in most cases) and the distal tubule-acting diuretics (hydrochlorothiazide).