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[Comparison between the effects of (-)- and (+)-gossypol on protein kinase C and protein kinase A]
D M Xiao1, W H Zhou, Y H Zhang
1Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|January 1, 1993
Abstract:
Protein kinase C(PKC) and protein kinase A(PKA) purified from rat liver were incubated with (-)- and (+)-gossypol. The activity of PKC was significantly inhibited in a concentration-dependent manner by both (-)-gossypol and (+)-gossypol. (-)-gossypol was found to inhibit type I PKA, whereas the inhibitory action of (+)-gossypol for type I PKA was less potent. Both (-)-gossypol and (+)-gossypol showed inhibition for type II PKA only at high concentration. These results suggest that administration of gossypol might impair cellular signal transduction.