[Study on cisplatin albumin microspheres for neck external artery embolization]

Area of Science:

• Biomedical Engineering
• Oncology
• Materials Science

Background:

• Jaw squamous cell carcinoma requires effective localized treatment strategies.
• Chemotherapy delivery via arterial embolization offers targeted drug administration.
• Albumin-based drug delivery systems show potential for controlled release and biocompatibility.

Purpose of the Study:

• To prepare and characterize cisplatin albumin microspheres for targeted embolization therapy in jaw squamous cell carcinoma.
• To evaluate the in vitro release, stability, and sterilization of the microspheres.
• To assess the embolization capability and local retention of the microspheres in animal models.

Main Methods:

• Emulsion chemical-crosslinking technique for microsphere preparation.
• Characterization of microsphere yield, size, cisplatin concentration, and loading rate.
• In vitro release studies, sterilization, and stability assessments.
• Animal testing to evaluate embolization efficacy and local retention.

Main Results:

• Yellow microspheres were successfully prepared with 80 +/- 5% yield and a mean size of 56.3 microns.
• High cisplatin concentration (14.02-14.20%) and loading rate (97.08-97.95%) were achieved.
• In vitro studies confirmed microsphere characteristics, including release, sterilization, and stability.
• Animal tests demonstrated effective plugging of neck external artery branches and local tissue retention.

Conclusions:

• Cisplatin albumin microspheres are a viable formulation for targeted embolization in jaw squamous cell carcinoma.
• The prepared microspheres exhibit favorable characteristics for localized chemotherapy delivery.
• The study supports the potential of these microspheres for improving treatment outcomes in head and neck cancers.