Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Rigorous exercise training increases superoxide dismutase activity in ventricular myocardium

S K Powers1, D Criswell, J Lawler

  • 1Department of Exercise and Sport Sciences, University of Florida, Gainesville 32611.

The American Journal of Physiology
|December 1, 1993
PubMed
Summary

Endurance exercise, particularly high-intensity or long-duration moderate-intensity training, effectively boosts myocardial superoxide dismutase (SOD) activity in rats. Other antioxidant enzyme activities remained unchanged by the training regimens.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Exercise and beta-adrenergic regulation of rat cardiac myosin isoforms.

The Journal of sports medicine and physical fitness·1999
Same author

Adaptive strategies of respiratory muscles in response to endurance exercise.

Medicine and science in sports and exercise·1996
Same author

Effects of clenbuterol on contractile and biochemical properties of skeletal muscle.

Medicine and science in sports and exercise·1996
Same author

Pharmacokinetics of lamivudine administered alone and with trimethoprim-sulfamethoxazole.

Clinical pharmacology and therapeutics·1996
Same author

Peripheral administration of Interleukin-1 Receptor antagonist inhibits brain damage after focal cerebral ischemia in the rat.

Experimental neurology·1996
Same author

Functional recovery in parkinsonian monkeys treated with GDNF.

Nature·1996

Area of Science:

  • Exercise Physiology
  • Cardiovascular Research
  • Biochemistry

Background:

  • Myocardial antioxidant enzyme activity is crucial for cardiac health.
  • The precise impact of varying endurance training protocols on these enzymes remains debated.

Purpose of the Study:

  • To investigate the effects of different exercise intensities and durations on antioxidant enzyme activities in the rat ventricular myocardium.
  • To clarify the relationship between endurance training parameters and myocardial oxidative stress defense mechanisms.

Main Methods:

  • Female Fischer-344 rats underwent 10 weeks of treadmill exercise with varied durations (30-90 min/day) and intensities (low, moderate, high).
  • Activity levels of citrate synthase, catalase, glutathione peroxidase, and superoxide dismutase (SOD) were measured in the right and left ventricles.

Related Experiment Videos

Main Results:

  • Citrate synthase, catalase, and glutathione peroxidase activities were not significantly altered by any training protocol.
  • High-intensity exercise (all durations) significantly increased both right and left ventricular SOD activity.
  • Moderate-intensity exercise (90 min/day) and long-duration low-to-moderate intensity exercise (60-90 min/day) also elevated ventricular SOD activity.

Conclusions:

  • High-intensity endurance exercise (≥30 min/day) upregulates myocardial SOD activity.
  • Moderate-intensity exercise of longer duration (≥60 min/day) also enhances SOD activity in the ventricular myocardium.
  • Specific exercise intensity and duration are key factors in modulating cardiac antioxidant enzyme responses.