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Effects of phosphonylmethoxyalkyl derivatives studied with a murine model for abortion induced by equine herpesvirus
1Department of Clinical Veterinary Medicine, Cambridge University, United Kingdom.
Antimicrobial Agents and Chemotherapy
|November 1, 1993
Abstract:
(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine (HPMPA) and (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine (HPMPC) were tested in a mouse model for equine herpesvirus 1-induced abortion. HPMPA, given twice daily, reduced virus replication, but the compound was embryotoxic. A single dose of HPMPC, however, reduced the incidence of abortion and transfer of virus to the fetuses while producing no obvious toxic effects.