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Folliculitis in Down's syndrome
G M Kavanagh1, J P Leeming, G M Marshman
1Department of Dermatology, Bristol Royal Infirmary, U.K.
The British Journal of Dermatology
|December 1, 1993
Summary
Adults with Down syndrome experiencing Malassezia folliculitis saw significant rash improvement with oral itraconazole. Symptoms returned upon discontinuing the antifungal treatment, indicating its effectiveness.
Area of Science:
- Dermatology
- Mycology
- Genetics
Background:
- Down syndrome is associated with various dermatological conditions.
- Malassezia folliculitis is a common fungal infection affecting the skin.
Purpose of the Study:
- To investigate the prevalence of Malassezia folliculitis in adults with Down syndrome.
- To evaluate the efficacy of oral itraconazole in treating this condition in the studied population.
Main Methods:
- A cohort of adults with Down syndrome was examined for skin conditions.
- Patients with Malassezia folliculitis were treated with oral itraconazole.
- Skin Malassezia counts and rash severity were assessed before, during, and after treatment.
Main Results:
- A significant proportion of male and female adults with Down syndrome presented with Malassezia folliculitis.
- Oral itraconazole treatment led to marked improvement in the rash and reduced fungal load.
- Discontinuation of itraconazole resulted in clinical relapse with yeast re-emergence.
Conclusions:
- Malassezia folliculitis is prevalent in adults with Down syndrome.
- Oral itraconazole is an effective treatment for Malassezia folliculitis in this population.
- Antifungal therapy is crucial for managing Malassezia folliculitis, with potential for relapse upon cessation.