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Folliculitis in Down's syndrome

G M Kavanagh1, J P Leeming, G M Marshman

  • 1Department of Dermatology, Bristol Royal Infirmary, U.K.

The British Journal of Dermatology
|December 1, 1993
PubMed
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Adults with Down syndrome experiencing Malassezia folliculitis saw significant rash improvement with oral itraconazole. Symptoms returned upon discontinuing the antifungal treatment, indicating its effectiveness.

Area of Science:

  • Dermatology
  • Mycology
  • Genetics

Background:

  • Down syndrome is associated with various dermatological conditions.
  • Malassezia folliculitis is a common fungal infection affecting the skin.

Purpose of the Study:

  • To investigate the prevalence of Malassezia folliculitis in adults with Down syndrome.
  • To evaluate the efficacy of oral itraconazole in treating this condition in the studied population.

Main Methods:

  • A cohort of adults with Down syndrome was examined for skin conditions.
  • Patients with Malassezia folliculitis were treated with oral itraconazole.
  • Skin Malassezia counts and rash severity were assessed before, during, and after treatment.

Main Results:

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  • A significant proportion of male and female adults with Down syndrome presented with Malassezia folliculitis.
  • Oral itraconazole treatment led to marked improvement in the rash and reduced fungal load.
  • Discontinuation of itraconazole resulted in clinical relapse with yeast re-emergence.

Conclusions:

  • Malassezia folliculitis is prevalent in adults with Down syndrome.
  • Oral itraconazole is an effective treatment for Malassezia folliculitis in this population.
  • Antifungal therapy is crucial for managing Malassezia folliculitis, with potential for relapse upon cessation.