[The resistance to drainage of the aqueous humor]

The presence of the evacuation paths of aqueous humor at the level of the camerular angle makes it play an important role on open angle glaucoma pathology. The fundamental element in the evacuation of aqueous humor is the endothelial cell, who has a main contribution to the routing of aqueous humor using the phenomenon called micropinocytosis. With the age the number of endothelial cells diminishes, their function reduces and an atypical collagen appears, together with the thickness of the basal membrane, the agglutination of the trabecular blades and Schlemm channel collapse. The fact is that the raise of the evacuation resistance in open angle glaucoma must not be interpreted mechanically; a research from a biochemical and molecular point of view must be completed.